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Camptothecin | Topoisomerase I inhibitor

Camptothecin (7689-03-4) is a natural product isolated from the Chinese Happy Tree, Camptotheca acuminate. It is an inhibitor of DNA topoisomerase I. Camptothecin binds irreversibly to the topoisomerase I /DNA complex preventing DNA re-ligation and generating permanent double strand breaks. Potent antitumor agent.

References/Citations
1) Hsiang et al. (1985) Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.; J. Biol. Chem., 260 14873
2) Li et al. (2006) Review camptothecin: current perspectives; Curr. Med. Chem., 13 2021

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Focus Biomolecules cell signaling reagent supplier, structure of Camptothecin | Topoisomerase I inhibitor | CAS 7689-03-4

Catalog#  10-1041

$30.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
7689-03-4
Catalog Number:
10-1041
Activity:
Topoisomerase I inhibitor
Chemical Name:
(S)-4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Molecular Weight:
348.35
Molecular Formula:
C20H16N2O4
Solubility:
Soluble in DMSO (up to 5 mg/ml).
Physical Properties:
Tan solid
Purity:
98%
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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