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Capsaicin (natural) | TRPV1 agonist

Capsaicin (404-86-4) is a vanilloid agonist known to activate the transient receptor potential channel vanilloid subfamily member 1 (TRPV1)1,2 and to possess analgesic3, anti-inflammatory4 and hypolocomotor effects5.
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References/Citations
1) Gunthorpe et al. (2002) The diversity in the vanilloid (TRPV) receptor family of ion channels; Trends Pharmacol. Sci. 23 183
2) Van Der Stelt and Di Marzo (2004) Endovanilloids. Putative endogenous ligands of transient receptor potential vanilloid 1 channels; Eur. J. Biochem. 271 1827
3) Perkins and Campbell (1992) Capsazepine reversal of the antinociceptive action of capsaicin in vivo; Br. J. Pharmacol. 107 329
4) Kim et al..(2003) Capsaicin exhibits anti-inflammatory property by inhibiting IkB-a degradation in LPS-stimulated peritoneal macrophages; Cell. Signal., 15 299
5) Di Marzo et al. (2001) Hypolocomotor effects in rats of capsaicin and two long chain capsaicin homologues; Eur. J. Pharmacol., 420 123

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Capsaicin (natural) | TRPV1 agonist | CAS 404-86-4

Catalog#  10-2298

$80.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
404-86-4
Catalog Number:
10-2298
Activity:
TRPV1 agonist
Chemical Name:
8-Methyl-N-vanillyl-trans-6-nonenamide
Molecular Weight:
305.41
Molecular Formula:
C18H27NO3
Solubility:
Soluble in Ethanol (up to 25 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NOTE: product is a mixture of capsaicin and dihydrocapsaicin which are unresolvable by TLC.
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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