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Carnosic acid | Antioxidant

Carnosic acid (3650-09-7) is an antioxidant and free radical scavenger. Increases cellular levels of glutathione (GSH) and prevents 6-hydroxydopamine-induced cell death in SH-SY5Y cells1. Carnosic acid-stimulation of GSH inhibits adipocyte differentiation2. Induces apoptosis3 and inhibits the proliferation and migration of various tumor cell lines4.

References/Citations
1) Chen et al. (2012), Carnosic acid prevents 6-hydroxydopamine-induced cell death in SH-SY5Y cells via mediation of glutathione synthesis; Chem. Res. Toxicol., 25 1893
2) Takahashi et al. (2009), Carnosic acid and carnosol inhibit adipocyte differentiation in mouse 3T3-L1 cells through induction of phase2 enzymes and activation of glutathione metabolism; Biochem. Biophys. Res. Commun., 382 549
3) Kar et al. (2012), Carnosic acid modulates Akt/IKK/NFκB signaling by PP2A and induces intrinsic and extrinsic pathway mediated apoptosis in human prostate carcinoma PC-3 cells; Apoptosis, 17 735
4) Barni et al. (2012), Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells; Oncol. Rep., 27 1041

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Carnosic acid | Antioxidant | CAS 3650-09-7

Catalog#  10-2401

$40.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
637964
Catalog Number:
10-2401
Activity:
antioxidant
Chemical Name:
Natural diterpenoid resorcinol isolated from Rosmarinus officinalis.
Molecular Weight:
332.42
Molecular Formula:
C20H28O4
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Off-white or yellow solid
Purity:
95% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 3 years as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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