CBR-470-1 | NRF2 signaling activator

CBR-470-1 Supplier | CAS 2416095-06-0 | Focus Biomolecules

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Cancer Cell Metabolism Library

CBR-470-1 (2416095-06-0) is an activator of NRF2 signaling (EC50 ~ 1 µM cellular ARE-LUC assay).1 It inhibits phosphoglycerate kinase 1 leading to a build-up of methylglyoxal which inactivates KEAP1. It protected SH-SY5Y neuronal cells from MPP+ induced oxidative injury via activation of NRF2 signaling.2

References/Citations:

  1. Bollong et al. (2018) A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling; Nature 562 600
  2. Zheng et al. (2020) PGK1 inhibitor CBR-470-1 protects neuronal cells from MPP+; Aging (Albany NY) 12 13388
2416095-06-0, CBR-470-1, CBR-470-1 supplier, Nrf2 activator, PGK1 inhibitor, Phosphoglycerate kinase 1 inhibitor
Alternate Name:
Curaxin 137

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

CBR-470-1 (2416095-06-0) is an activator of NRF2 signaling (EC50 ~ 1 µM cellular ARE-LUC assay).1 It inhibits phosphoglycerate kinase 1 leading to a build-up of methylglyoxal which inactivates KEAP1. It protected SH-SY5Y neuronal cells from MPP+ induced oxidative injury via activation of NRF2 signaling.2

References/Citations:

  1. Bollong et al. (2018) A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling; Nature 562 600
  2. Zheng et al. (2020) PGK1 inhibitor CBR-470-1 protects neuronal cells from MPP+; Aging (Albany NY) 12 13388

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