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Product Details

Celecoxib | COX II inhibitor

Celecoxib (169590-42-5) is a selective inhibitor of cyclooxygenase-2 (COX-2) IC50 = 15 and 0.04 μM for COX-1 and COX-2 respectively.1 Potent and clinically useful antiinflammatory agent.2 Cancer chemopreventive agent.3 Celecoxib may act synergistically with currently used anticancer agents.4 Cell permeable, active in vivo.

References/Citations
1) Penning . (1997), Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib); J. Med. Chem., 40 1347
2) DeWitt et al. (1999), Cox-2-selective inhibitors: the new super aspirins; Mol. Phamracol., 55 625
3) Harris et al. (2000), Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor; Cancer Res., 60 2101
4) Koki and Masferrer et al. (2002), Celecoxib: a specific COX-2 inhibitor with anticancer properties; Cancer Control, 9 28

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Catalog#  10-2124

$35.00
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CAS:
169590-42-5
Catalog Number:
10-2124
Activity:
COX II inhibitor
Alternate Names:
SC-58635
Chemical Name:
4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide
Molecular Weight:
381.38
Molecular Formula:
C17H14F3N3O2S
Solubility:
Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml).
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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