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  • Focus Biomolecules reagent supplier, chemical structure of 1,4-DPCA | Prolyl hydroxylase inhibitor | CAS 331830-20-7
    1,4-DPCA (331830-20-7) is a potent inhibitor of prolyl 4-hydroxylase (IC50=2-4 μM)1. Inhibits collagen deposition via inhibition of collagen proline hydroxylation2,3. Subcutaneous injection of a 1,4-DPCA containing...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Amifostine | Cellular protectant | CAS 20537-88-6
    Amifostine (20537-88-6) is a broad sprectrun radio- and chemoprotective agent.1 Prevents chemotherapy-induced apoptosis, upregulates HIF-1α and restores transcriptional activity in specific p53 mutants.2-4...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Apicidin | HDAC inhibitor | CAS 183506-66-3
    Apicidin (183506-66-3) is a fungal toxin that is a potent, cell permeable inhibitor of histone deacetylases (HDAC's).1 It also displays antitumor properties by inducing changes in p21WAF1/Cip1 and gelsolin gene expression...

  • Focus Biomolecules cell signaling reagent supplier, structure of Apigenin | Protein kinase inhibitor | CAS 520-36-5
    Apigenin (520-36-5) is a plant flavonoid with antioxidant properties. It has been reported to have myriad effects on biochemical pathways including kinase inhibition (CK2, PKC, ERK)1-3, CYP2CP inhibition4, inhibition of...

  • Focus Biomolecules chemical structure of DMOG | Inhibits prolyl hydroxylase domain-containing proteins | CAS 89464-63-1
    DMOG (89464-63-1) inhibits PHD or prolyl hydroxylase domain-containing proteins, activating HIF1α1,2 and inhibiting JMJD2A (IC50 = 2.5 μM)3. Displays neuroprotective effects. Inhibits neuronal cell death caused by...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Echinomycin | HIF-1alpha inhibitor | CAS 512-64-1
    Echinomycin (CAS 512-64-1) is a potent and selective hypoxia inducible factor 1α (HIF-1α) inhibitor. It binds to DNA via bifunctional intercalation, blocking the interaction of HIF-1α.1 Protects mice...

  • Focus Biomolecules cell signaling supplier, chemical structure of HIF-2alpha-I2 | HIF-2alpha antagonist | CAS 1422955-31-4
    HIF-2α-I2 (1422955-31-4) is a potent and selective HIF-2α inhibitor, Kd=81 nM.1 Binds to the HIF-2α PAS-B domain2 and interferes with Hif-2α / ARNT heterodimerization reducing target gene expression...

  • Focus Biomolecules supplier, chemical structure of Hinokitiol | Iron Chelator antioxidant | CAS 499-44-5
    Hinokitiol (499-44-5) is a potent metal chelator that induces differentiation and apoptosis in teratocarcinoma F9 cells.1 It acts as a reversible inhibitor of platelet-type 12-lipoxygenase (IC50 = 100 nM).2 Hinokitiol is...

  • KC7F2 | HIF-1alpha inhibitor
    KC7F2 is an inhibitor of HIF-1α (IC50 = 20 µM).1 It inhibited HIF-mediated transcription in cells derived from glioma, breast, and prostate cancers. The mechanism of action of KC7F2 is via down-regulation of...

  • Manumycin A | Farnesyltransferase inhibitor
    Manumycin A (52665-74-4) inhibits ras farnesyltransferase1 and prevents ras signaling2. Irreversibly inhibits neutral sphingomyelinase3. Abrogates IL-1β-induced HIF-1α activation in both glioma and non-glioma...

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