Leptomycin B (87081-35-4) is an inhibitor of nuclear export of proteins. Acts via covalent binding to and inhibiting CRM1/exportin-11. Inhibits the nuclear export of the HIV regulatory protein Rev2. Leptomycin B stabilizes p53 by blocking its nuclear export3.
1) Kudo et al. (1998), Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1; Exp. Cell Res., 242 540
2) Wolff et al. (1997), Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA; Chem. Biol., 4 139
3) Freedman and Levine (1998), Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6; Mol. Cell. Biol., 18 7288