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Product Details

Leptomycin B | Nuclear export inhibitor

Leptomycin B (87081-35-4) is an inhibitor of nuclear export of proteins. Acts via covalent binding to and inhibiting CRM1/exportin-11. Inhibits the nuclear export of the HIV regulatory protein Rev2. Leptomycin B stabilizes p53 by blocking its nuclear export3.

1) Kudo et al. (1998), Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1; Exp. Cell Res., 242 540
2) Wolff et al. (1997), Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA; Chem. Biol., 4 139
3) Freedman and Levine (1998), Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6; Mol. Cell. Biol., 18 7288

Focus Biomolecules supplier, chemical structure of Leptomycin B | Nuclear export inhibitor | CAS 87081-35-4

Catalog#  10-2084-0200

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Catalog Number:
Nuclear export inhibitor
Molecular Weight:
Molecular Formula:
Supplied in solution in ethanol (1 mg/ml). Further dilutions may be made with either ethanol or DMSO.
Physical Properties:
Solution in ethanol (1mg/ml)
99% by HPLC
NMR (Conforms)
Storage Temperature:
Stable for 1 year as supplied. Solutions or dilutions in DMSO are not stable. Solutions should be made fresh and used within one working day.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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