CGS 15943 | Adenosine receptor antagonist

CAS:
 104615-18-1
Catalog Number:
 10-4907
CGS 15943 chemical structure

Available Options

Size:PriceQuantity 
5 mg$40.00
25 mg$155.00
Request Quote / Bulk / Custom Size
Product Inquiry

CGS 15943 (104615-18-1) is a potent adenosine receptor antagonist (IC50s: A1 = 21 nM; A2 = 3.3 nM).1,2 It has also been reported to be an activator of the aryl hydrocarbon receptor (AhR; EC50 = 96 nM) with pro-apoptotic effects in mouse and human liver and triple negative breast cancer cells3 and in lung cancer cells4. CGS 15943 displayed cardiac anti-fibrotic activity via adenosine receptor-dependent activation of PI3K-AKT and YAP leading to reduction of both fibrotic gene expression and fibroblast activation.5

References/Citations:

  1. Francis et al. (1988), Structure-Activity Profile of a Series of Novel Triazoloquinazoline Adenosine Antagonists; J. Med. Chem. 31 1014
  2. Ghai et al. (1987), Pharmacological characterization of CGS 15943A: a novel nonxanthine adenosine antagonist; J. Pharmacol. Exp. Ther. 242 784
  3. O’Donnell et al. (2021), Discovery and Mechanistic Characterization of a Select Modulator of AhR-regulated Transcription (SMAhRT) with Anti-cancer Effects; Apoptosis 26 307
  4. Nguten and Kolluri (2026), Genome-wide CRISPR screen reveals CGS-15943 induced heme-dependent cell death mediated by aryl hydrocarbon receptor in lung cancer cells; Apoptosis 31 204
  5. Zhang et al. (2026), Targeting and atypical G protein-coupled receptor signaling pathway for cardiac fibrosis therapy; Science 393 eaej5896
104615-18-1, A1 antagonist, A2 antagonist, adenosine antagonist, adenosine receptor antagonist, CGS 15943, CGS 15943 supplier, CGS15943 supplier
CAS:
104615-18-1
Catalog Number:
10-4907
Activity:
Adenosine receptor antagonist
Chemical Names:
9-Chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine
Molecular Weight:
285.69
Molecular Formula:

C13H8ClN5O

Solubility:
Soluble in DMSO (10 mg/ml with warming)
Physical Properties:
Off-white solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

Download Safety Data Sheet

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

CGS 15943 (104615-18-1) is a potent adenosine receptor antagonist (IC50s: A1 = 21 nM; A2 = 3.3 nM).1,2 It has also been reported to be an activator of the aryl hydrocarbon receptor (AhR; EC50 = 96 nM) with pro-apoptotic effects in mouse and human liver and triple negative breast cancer cells3 and in lung cancer cells4. CGS 15943 displayed cardiac anti-fibrotic activity via adenosine receptor-dependent activation of PI3K-AKT and YAP leading to reduction of both fibrotic gene expression and fibroblast activation.5

References/Citations:

  1. Francis et al. (1988), Structure-Activity Profile of a Series of Novel Triazoloquinazoline Adenosine Antagonists; J. Med. Chem. 31 1014
  2. Ghai et al. (1987), Pharmacological characterization of CGS 15943A: a novel nonxanthine adenosine antagonist; J. Pharmacol. Exp. Ther. 242 784
  3. O’Donnell et al. (2021), Discovery and Mechanistic Characterization of a Select Modulator of AhR-regulated Transcription (SMAhRT) with Anti-cancer Effects; Apoptosis 26 307
  4. Nguten and Kolluri (2026), Genome-wide CRISPR screen reveals CGS-15943 induced heme-dependent cell death mediated by aryl hydrocarbon receptor in lung cancer cells; Apoptosis 31 204
  5. Zhang et al. (2026), Targeting and atypical G protein-coupled receptor signaling pathway for cardiac fibrosis therapy; Science 393 eaej5896

STEM CELL

BOGO