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Chaetocin | Lys methyltransferase inhibitor
Chaetocin (28097-69-1) is an antimicrobial fungal metabolite. Selective inhibitor of lysine specific histone methtransferase1. Chaetocin has an antimyeloma activity which has been linked to induction of oxidative stress and subsequent apoptosis2.
References/Citations
1) Greiner et al. (2005), Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9; Nat. Chem. Biol., 1 143
2) Isham et al. (2007), Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress; Blood, 109 2579
Catalog# 10-2404-0200
$40.00
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CAS:
28097-03-2
Catalog Number:
10-2404
Activity:
Lys methyltransferase inhibitor
Chemical Name:
Isolated from Chaetomium species
Molecular Weight:
696.85
Molecular Formula:
C30H28N6O6S4
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98%
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
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