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Chaetoglobosin A | Actin binding agent / Apoptosis inducer

Chaetoglobosin A (50335-03-0) is a cytochalasin analog which targets filamentous actin. Displays cytotoxic effects against human colorectal HCT116 cells, IC50=3.15 μM.1 Preferentially induces apoptosis in chronic lymphocytic leukemia cells via targeting the cytoskeleton.2 Enhances the fibrinolytic activity of vascular endothelial cells.3

References/Citations

1) Li et al. (2014), Chaetoglobosins from Chaetomium globosum, an endophytic fungus in Ginkgo biloba, and their phytotoxic and cytotoxic activities; J. Agric. Food Chem., 62 3734
2) Knudsen et al. (2014), Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton; Leukemia, 28 1289
3) Shinohara et al. (2000), Enhancement of fibrinolytic activity of vascular endothelial cells by chaetoglobosin A, crinipellin B, geodin and triticone B; J. Antibiot. (Tokyo), 53 262

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Focus Biomolecules supplier, chemical structure Chaetoglobosin A | Actin binding agent | Apoptosis inducer | CAS 50335-03-0

Catalog#  10-3081-0001

$94.00
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CAS:
50335-03-0
Catalog Number:
10-3081
Activity:
Actin binding agent / Apoptosis inducer
Chemical Name:
(7S,13E, 16S, 17E, 19R, 21E)-6,7-Epoxy-19-hydroxy-10-(1H-indol-3-yl)-16,18-dimethyl-[13]cytochalasa- 13,17,21-triene-1,20,23-trione
Molecular Weight:
528.64
Molecular Formula:
C32H36N2O5
Solubility:
Soluble in DMSO (up to 5 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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