Chroman 1 | ROCK II inhibitor / Stem cell cytoprotectant
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 1 mg | $45.00 | ||
| 5 mg | $185.00 |
Chroman 1 (1273579-40-0) is an extremely potent inhibitor of Rho kinase II (ROCK-II)1,2 – it displayed greater selectivity and potency compared to Y-27632 (IC50’s: ROCK I = 52 pM/ROCK II = 1 pM; Y-27632 IC50’s: ROCK I = 71 nM/ROCK II = 46 nM)3. Chroman 1, used in conjunction with trans-ISRIB (Cat# 10-1539), Emricasan (Cat# 10-4280), and polyamines (CEPT cocktail), promotes cytoprotective cell survival in human pluripotent stem cells (hPSCs) and was found to be superior to Y-27632.3 Chroman 1 is an important new tool in the generation and maintenance of stem cells.
References/Citations:
- Chen et al. (2011), Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors; Med. Chem. Commun.,2 73
- Chen et al. (2008), Chroman-3-amides as potent Rho kinase inhibitors; Bioorg. Med. Chem. Lett., 18 6406
- Chen et al. (2021), A Versatile Polypharmacology Platform Promotes Cytoprotection and Viability of Human Pluripotent and Differentiated Cells; Nat. Methods, 18 528
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Chroman 1 (1273579-40-0) is an extremely potent inhibitor of Rho kinase II (ROCK-II)1,2 – it displayed greater selectivity and potency compared to Y-27632 (IC50’s: ROCK I = 52 pM/ROCK II = 1 pM; Y-27632 IC50’s: ROCK I = 71 nM/ROCK II = 46 nM)3. Chroman 1, used in conjunction with trans-ISRIB (Cat# 10-1539), Emricasan (Cat# 10-4280), and polyamines (CEPT cocktail), promotes cytoprotective cell survival in human pluripotent stem cells (hPSCs) and was found to be superior to Y-27632.3 Chroman 1 is an important new tool in the generation and maintenance of stem cells.
References/Citations:
- Chen et al. (2011), Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors; Med. Chem. Commun.,2 73
- Chen et al. (2008), Chroman-3-amides as potent Rho kinase inhibitors; Bioorg. Med. Chem. Lett., 18 6406
- Chen et al. (2021), A Versatile Polypharmacology Platform Promotes Cytoprotection and Viability of Human Pluripotent and Differentiated Cells; Nat. Methods, 18 528
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
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1-855-FOCUS21
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