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Emricasan | pan-Caspase inhibitor

CAS:
254750-02-2
Catalog Number:
10-4280
Activity:
pan-Caspase inhibitor
Chemical Names:
(3S)-3-[[(2S)-2-[[2-(2-tert-butylanilino)-2-oxoacetyl]amino]propanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
Alternate Name:
IDN-6556; PF-03491390
Molecular Weight:
569.51
Molecular Formula:
C26H27F4N3O7
Solubility:
Soluble in DMSO (20 mg/ml)
Physical Properties:
White solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Emricasan (254750-02-2) is a liver-targeted antiapoptotic pan-caspase inhibitor.1,2 It has been investigated as a hepatoprotective agent in the treatment of liver ischemia3 and  NASH/NAFLD liver injury4,5. Emricasan protected SNB-19 cells against cell death induced by Zika virus strains MR766, FSS13025, and PRVABC59.6 Emricasan improves the viability of hPSCs and their differentiated progeny when used in a small molecule cocktail (CEPT) containing chroman 1 (Cat# 10-4912), polyamines, and trans-ISRIB (Cat# 10-1539).7

References/Citations:

  1. Linton et al. (2005), First-in-class Pan Caspase Inhibitor for the Treatment of Liver Disease; J. Med. Chem., 48 6779
  2. Hoglen et al. (2004), Characterization of IDN-6556 (3-{2-(2-tert-Butylphenylaminooxalyl)-amino]-propionylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)-pentanoic Acid): a Liver-Targeted Caspase Inhibitor; J. Pharmacol. Exp. Ther., 309 634
  3. Hoglen et al. (2007), A caspase inhibitor, IDN-6556, ameliorates early hepatic injury in an ex vivo rat model of warm and cold ischemia; Liver Transpl., 13 361
  4. Barreyro et al. (2015), The pan-caspase inhibitor Emricasan (IDN-5665) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis; Liver Int., 35 953
  5. Frenette et al. (2019), Emricasan Improves Liver Function in Patients With Cirrhosis and High Model for End-Stage Liver Disease Scores Compared With Placebo; Clin. Gastroenterol. Hepatol., 17 774
  6. Xu et al. (2016), Identification of small molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen; Nat. Med., 22 1101
  7. Chen et al. (2021), A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cells; Nat. Methods, 18 528
Emricasan | pan-Caspase inhibitor is also available in the Cellular Metabolism Library.
CAS:
254750-02-2
Catalog Number:
10-4280
Activity:
pan-Caspase inhibitor
Chemical Names:
(3S)-3-[[(2S)-2-[[2-(2-tert-butylanilino)-2-oxoacetyl]amino]propanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
Alternate Name:
IDN-6556; PF-03491390
Molecular Weight:
569.51
Molecular Formula:
C26H27F4N3O7
Solubility:
Soluble in DMSO (20 mg/ml)
Physical Properties:
White solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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