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Cinnabarinic acid | Endogenous AhR ligand

Cinnabarinic acid (606-59-7) is a novel endogenous tryptophan metabolite which acts as an aryl hydrocarbon receptor (AHR) agonist.1 It drives IL-22 production by stimulating the differentiation of human and mouse T cells producing IL-22.1 Induces apoptosis in thymocytes.2 Activates type 4 metabotropic glutamate receptors.3 Cinnabarinic acid counteracts excitotoxic neuronal cell death induced by NMDA in mixed cultures of cortical cells. Displays neuroprotective activity.3


1) Lowe et al. (2014), Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production;  PLoS One, 9(2) e87877
2) Hiramatsu et al. (2008), Cinnabarinic acid generated from 3-hydroxyanthranilic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspase;  J. Cell. Biochem., 103 42
3) Fazio et al. (2012), Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors;  Mol. Pharmacol., 81 643

Focus Biomolecules cell signaling supplier, chemical structure of Cinnabarinic acid | Endogenous AhR ligand | CAS 606-59-7

Catalog#  10-2883

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Catalog Number:
Endogenous AhR ligand
Chemical Name:
2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid
Alternate Names:
Cinnabaric acid
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 30 mg/ml) or in DMF (up to 25 mg/ml).
Physical Properties:
Red solid
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 2 years as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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