my account
Login
  Loading... Please wait...

Product Details

Cinnabarinic acid | Endogenous AhR ligand

Cinnabarinic acid (606-59-7) is a novel endogenous tryptophan metabolite which acts as an aryl hydrocarbon receptor (AHR) agonist.1 It drives IL-22 production by stimulating the differentiation of human and mouse T cells producing IL-22.1 Induces apoptosis in thymocytes.2 Activates type 4 metabotropic glutamate receptors.3 Cinnabarinic acid counteracts excitotoxic neuronal cell death induced by NMDA in mixed cultures of cortical cells. Displays neuroprotective activity.3

References/Citations

1) Lowe et al. (2014), Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production;  PLoS One, 9(2) e87877
2) Hiramatsu et al. (2008), Cinnabarinic acid generated from 3-hydroxyanthranilic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspase;  J. Cell. Biochem., 103 42
3) Fazio et al. (2012), Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors;  Mol. Pharmacol., 81 643

swipe
Focus Biomolecules cell signaling supplier, chemical structure of Cinnabarinic acid | Endogenous AhR ligand | CAS 606-59-7

Catalog#  10-2883

$50.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
606-59-7
Catalog Number:
10-2883
Activity:
Endogenous AhR ligand
Chemical Name:
2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid
Alternate Names:
Cinnabaric acid
Molecular Weight:
300.22
Molecular Formula:
C14H8N2O6
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in DMF (up to 25 mg/ml).
Physical Properties:
Red solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the Cinnabarinic acid | Endogenous AhR ligand to your wish list.