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CL-316243 | beta 3-adrenergic agonist / antiobesity

CL-316243 (151126-84-0) is a potent and selective β-3 adrenergic receptor agonist. (EC50= 3 nM) Displays anti-obesity and anti-diabetic effects in mice. It increases brown fat thermogenesis and metabolic rate and decreases blood insulin and glucose levels.1 CL-316243 induces functionally active mitochondrial uncoupling protein (UCP) in white fat.2 Active in vivo.

References/Citations
1) Yoshida et al. (1994), Anti-obesity and anti-diabetic effects of CL 316,243, a highly specific beta 3-adrenoceptor agonist in yellow KK mice; Life Sci., 54 491
2) Yoshida et al. (1998), β3-Adrenergic agonist induces a functionally active uncoupling protein in fat and slow-twitch muscle fibers; Am. J. Physiol., 274 E469

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CL-316243 | 151126-84-0 | Structure | Supplier

Catalog#  10-1450

$80.00
Quantity
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CAS:
151126-84-0
Catalog Number:
10-1450
Activity:
β3-adrenergic agonist / antiobesity
Chemical Name:
5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid disodium salt
Molecular Weight:
465.8
Molecular Formula:
C20H18ClNNa2O7
Solubility:
Soluble in Water (up to 50 mg/ml).
Physical Properties:
Off-white solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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