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Clodronate 2Na | Induces osteoclast apoptosis

Clodronate 2Na (88416-50-6) is a first generation non-nitrogenous bisphosphonate drug for the prevention and treatment of osteoporosis and skeletal fractures/hypercalcemia in patients with cancer.  It strongly binds to hydroxyapatite and directly reduces osteoclast activity.Clodronate is metabolized in vitro to a cytotoxic ATP analog (AppCCl2p) which inhibits ADP/ATP translocase in the mitochondrial inner membrane leading to osteoclast apoptosis.2

References/Citations

1) Plosker and Goa (1994), Clodronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease; Drugs 47 945
2) Lehenkari et al. (2002), Further Insight into Mechanism of Action of Clodronate: Inhibition of Mitochondrial ADP/ATP Translocase by a Nonhydrolyzable, Adenine-Containing Metabolite; Mol.Pharmacol. 61 1255

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Focus Biomolecules reagent supplier, chemical structure of Clodronate 2Na | Induces osteoclast apoptosis | CAS 88416-50-6

Catalog#  10-4631-0010

$30.00
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CAS:
88416-50-6
Catalog Number:
10-4631
Activity:
Induces osteoclast apoptosis
Chemical Name:
Dichloromethylenediphosphonic acid disodium tetrahydrate
Molecular Weight:
360.92
Molecular Formula:
CH2Cl2O6P2 • 2Na &Bull; H2O
Solubility:
Soluble in Water (up to at least 10 mg/ml)
Physical Properties:
White solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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