Clonixeril | STING antagonist

CAS:
 21829-22-1
Catalog Number:
 10-4139
Clonixeril chemical structure

Available Options

SizePriceQuantity 
5 mg$95.00
25 mg$330.00
Request Quote / Bulk / Custom Size
Product Inquiry

Clonixeril (21829-22-1) is an ultra-potent antagonist of human STING.  It acts as a STING agonist at micromolar concentrations but is an antagonist in the 1 nM to 100 aM range in THP-1 cells.  Its antagonistic behavior occurs via modulation of STING oligomerization.

References/Citations::

  1. Sparks et al. (2025), Discovery of Clonixeril as a Sub-Femtomolar Modulator of the Human STING Receptor; ACS Cent. Sci. 11 994
21829-22-1, clonixeril, Clonixeril supplier, STING antagonist
CAS:
21829-22-1
Catalog Number:
10-4139
Activity:
STING antagonist
Chemical Names:
2,3-Dihydroxypropyl 2-(3-chloro-2-methylanilino)pyridine-3-carboxylate
Molecular Weight:
336.77
Molecular Formula:

C16H17ClN2O4

Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Pale yellow solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

Download Safety Data Sheet

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

Clonixeril (21829-22-1) is an ultra-potent antagonist of human STING.  It acts as a STING agonist at micromolar concentrations but is an antagonist in the 1 nM to 100 aM range in THP-1 cells.  Its antagonistic behavior occurs via modulation of STING oligomerization.

References/Citations::

  1. Sparks et al. (2025), Discovery of Clonixeril as a Sub-Femtomolar Modulator of the Human STING Receptor; ACS Cent. Sci. 11 994

STEM CELL

BOGO