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Clozapine | Dopamine D2/D4 antagonist

Clozapine (5786-21-0) is a dopamine D4 and D2 receptor antagonist. High affinity for the cloned rat dopamine D4 receptor (Ki < 20 nM).1 Atypical neuroleptic agent.2 Antagonist at 5HT2A, 5HT2C, 5HT3, 5HT6 and 5HT7 receptors.3,4

References/Citations

1) Seeman and Van Tol (1994), Dopamine receptor pharmacology;  Trends Pharmacol. Sci., 15 264
2) Ellenbroek et al. (1991), The involvement of dopamine D1 and D2 receptors in the effects of the classical neuroleptic haloperidol and the atypical neuroleptic clozapine;  Eur. J. Pharmacol., 196 103
3) Canton et al. (1990), Binding of the typical and atypical antipsychotics to 5-HT1C and 5-HT2 sites: clozapine potently interacts with 5-HT1C sites;  Eur. J. Pharmacol., 191 93
4) Kuoppamaki et al. (1993), Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists;  Eur. J. Pjharmacol., 245 179

 

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Focus Biomolecules cell signaling reagent supplier, chemical structure Clozapine | Dopamine D2/D4 antagonist | CAS 5786-21-0

Catalog#  10-1140-0050

$30.00
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CAS:
5786-21-0
Catalog Number:
10-1140
Activity:
Dopamine D2/D4 antagonist
Chemical Name:
8-Chloro-11-(4-methyl-1-piperazinyl)-5/H-dibenzo[b,e]diazepine
Molecular Weight:
326.82
Molecular Formula:
C18H19ClN4
Solubility:
Soluble in DMSO (up to 30 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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