CNP7 | HMG-CoA synthase 1 inhibitor

CAS:
 N/A
Catalog Number:
 10-4045

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CNP7 is a first-in-class covalent inhibitor of HMG-CoA synthase 1, the first enzyme in the mevalonate pathway.  Treatment of HCT116 cells with 5 µM CNP7 lead to a significant reduction in HMG-CoA levels and increased levels of unprenylated proteins. It caused cell death in HEK293T and HCT116 cells due to a reduction in geranylgeranyl pyrophosphate levels. An interesting new tool for investigating mevalonate metabolism.

References/Citations:

  1. Sun et al. (2026) Comprehensive Chemoproteomics Unveils Selective HMG-CoA Synthase 1 Inhibitors for Targeting Mevalonate Metabolism in Cancer; J. Am. Chem. Soc. 148 20705
CNP7, CNP7 supplier, HMG-CoA synthase inhibitor
CAS:
N/A
Catalog Number:
10-4045
Activity:
HMG-CoA synthase 1 inhibitor
Chemical Names:
(S)-1-Cyano-N-((3'-(prop-2-yn-1-ylcarbamoyl)-[1,1'-biphenyl]-3-yl)methyl)pyrrolidine-3-carboxamide
Molecular Weight:
386.46
Molecular Formula:

C23H22N4O2

Solubility:
Soluble in DMSO (90 mg/ml)
Physical Properties:
Off-white solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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CNP7 is a first-in-class covalent inhibitor of HMG-CoA synthase 1, the first enzyme in the mevalonate pathway.  Treatment of HCT116 cells with 5 µM CNP7 lead to a significant reduction in HMG-CoA levels and increased levels of unprenylated proteins. It caused cell death in HEK293T and HCT116 cells due to a reduction in geranylgeranyl pyrophosphate levels. An interesting new tool for investigating mevalonate metabolism.

References/Citations:

  1. Sun et al. (2026) Comprehensive Chemoproteomics Unveils Selective HMG-CoA Synthase 1 Inhibitors for Targeting Mevalonate Metabolism in Cancer; J. Am. Chem. Soc. 148 20705

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