Compound E | gamma-secretase inhibitor

Available Options

Size:PriceQuantity 
1 mg$155.00
5 mg$500.00
Request Quote / Bulk / Custom Size
Product Inquiry

Compound E (209986-17-4) is a potent and selective, cell permeable inhibitor of γ-secretase which inhibits the cleavage of both amyloid precursor protein and Notch, IC50s ~ 3 nM.1,2 Inhibits growth and induces differentiation of neuroblastoma cells.3 Induces stem cell neuronal differentiation.4

References/Citations:

  1. Beher et al. (2001), Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology; J. Biol. Chem., 276 45394
  2. Zhao et al. (2004), Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein; J. Biol. Chem., 279 50647
  3. Ferrari-Toninelli et al. (2010), Targeting Notch pathway induces growth inhibition and differentiation of neuroblastoma cells; Neuro. Oncol., 12 1231
  4. Li et al. (2011), Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors; Proc. Natl. Acad. Sci. USA, 108 8299
209986-17-4, Compound E, Compound E supplier, Supplier

Safety Data Sheet:

Download Safety Data Sheet

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

Compound E (209986-17-4) is a potent and selective, cell permeable inhibitor of γ-secretase which inhibits the cleavage of both amyloid precursor protein and Notch, IC50s ~ 3 nM.1,2 Inhibits growth and induces differentiation of neuroblastoma cells.3 Induces stem cell neuronal differentiation.4

References/Citations:

  1. Beher et al. (2001), Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology; J. Biol. Chem., 276 45394
  2. Zhao et al. (2004), Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein; J. Biol. Chem., 279 50647
  3. Ferrari-Toninelli et al. (2010), Targeting Notch pathway induces growth inhibition and differentiation of neuroblastoma cells; Neuro. Oncol., 12 1231
  4. Li et al. (2011), Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors; Proc. Natl. Acad. Sci. USA, 108 8299