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Product Details

Cordycepin | AMPK activator

Cordycepin (73-03-0) is an adenosine analog lacking the hydroxyl at the 3’ position. Inhibits PARP1 and polyadenylation2. Displays anti-inflammatory effects1,3 and neuroprotective effects by inhibiting Aβ-induced apoptosis in hippocampal neurons4. Induces apoptosis in a variety of cancer cell lines5. Displays antiobesity effects.6 Inhibits cell senescence via activation of AMPK.7 Maintains stem cell pluripotency and increases iPS cell generation efficiency.8


1) Kim et al. (2011), Cordycepin blocks lung injury-associated inflammation and promotes BRCA1-deficient breast cancer cell killing by effectively inhibiting PARP; Mol. Med. 17 893
2) Kondrashov et al. (2012), Inhibition of polyadenylation reduces inflammatory gene induction; RNA 18 2236
3)Yang et al. (2017), Cordycepin inhibits LPS-induced inflammatory response by modulating NOD-Like Receptor Protein 3 inflammasome activation; Biomed. Pharmacother. 95 1777
4) Song et al. (2018), Neuroprotective efects of cordycepin inhibit Aβ-induced apoptosis in hippocampal neurons; Neurotoxicology 68 73
5) Zhang et al. (2018), Cordycepin induces apoptosis in human pancreatic cancer cells via the mitochondrial-mediated intrinsic pathway and suppresses tumor growth in vivo; OncoTargets Ther. 11 4479
6) Li et al. (2018), Cordycepin modulates body weight by reducing prolactin via an adenosine A1 receptor; Curr. Pharm. Des., 24 3240
7) Wang et al (2019) Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and SMPK in rodents; Nat. Commun. 10 2538
8) Wang et al. (2020) The novel application of cordycepin in maintaining stem cell pluripotency and increasing iPS cell generation efficiency; Sci. Rep. 10 2187

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Catalog#  10-2408-0010

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Catalog Number:
AMPK activator
Chemical Name:
Alternate Name:
NSC 63984
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
98% byHPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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