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Product Details

Cordycepin | AMPK activator

Cordycepin (73-03-0) is an adenosine analog lacking the hydroxyl at the 3’ position. Inhibits PARP1 and polyadenylation2. Displays anti-inflammatory effects1,3 and neuroprotective effects by inhibiting Aβ-induced apoptosis in hippocampal neurons4. Induces apoptosis in a variety of cancer cell lines5. Displays antiobesity effects.6 Inhibits cell senescence via activation of AMPK.7 Maintains stem cell pluripotency and increases iPS cell generation efficiency.8

 

References/Citations
1) Kim et al. (2011), Cordycepin blocks lung injury-associated inflammation and promotes BRCA1-deficient breast cancer cell killing by effectively inhibiting PARP; Mol. Med. 17 893
2) Kondrashov et al. (2012), Inhibition of polyadenylation reduces inflammatory gene induction; RNA 18 2236
3)Yang et al. (2017), Cordycepin inhibits LPS-induced inflammatory response by modulating NOD-Like Receptor Protein 3 inflammasome activation; Biomed. Pharmacother. 95 1777
4) Song et al. (2018), Neuroprotective efects of cordycepin inhibit Aβ-induced apoptosis in hippocampal neurons; Neurotoxicology 68 73
5) Zhang et al. (2018), Cordycepin induces apoptosis in human pancreatic cancer cells via the mitochondrial-mediated intrinsic pathway and suppresses tumor growth in vivo; OncoTargets Ther. 11 4479
6) Li et al. (2018), Cordycepin modulates body weight by reducing prolactin via an adenosine A1 receptor; Curr. Pharm. Des., 24 3240
7) Wang et al (2019) Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and SMPK in rodents; Nat. Commun. 10 2538
8) Wang et al. (2020) The novel application of cordycepin in maintaining stem cell pluripotency and increasing iPS cell generation efficiency; Sci. Rep. 10 2187

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Catalog#  10-2408-0010

$40.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
73-03-0
Catalog Number:
10-2408
Activity:
AMPK activator
Chemical Name:
3’-Deoxyadenosine
Alternate Name:
NSC 63984
Molecular Weight:
251.24
Molecular Formula:
C10H13N5O3
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% byHPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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