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Product Details

CPI-444 | Adenosine A2A receptor antagonist

CPI-444 (1202402-40-1) is a potent (Ki = 3.54 nM) and selective adenosine A2A receptor antagonist. It blocked the induction of cAMP induced by NECA in HEK-293 cells with an IC50 = 17.03 nM. CPI-444 monotherapy or in combination with anti-PD-1, anti-PD-L1, and anti-CTLA-4 induced T-cell-mediated tumor responses, inhibited tumor growth, and enabled antitumor immune memory.1,2 Currently in clinical trials for multiple cancers.3

References/Citations

1) Willingham et al. (2018), A2AR Antagonism with CPI-444 Induces Antitumor Responses and Augments Efficacy to Anti-PD-(L)1 and Anti-CTLA-4 in Preclinical Models; Cancer Immunol. Res. 6 1136
2) Leone et al. (2018), ), Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models; Cancer Immunol. Immunother. 671271
3) NCT02655822

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Catalog#  10-4101-0005

$95.00
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CAS:
1202402-40-1
Catalog Number:
10-4101
Activity:
Adenosine A2A receptor antagonist
Chemical Name:
7-(5-methylfuran-2-yl)-3-[[6-[[(3S)-oxolan-3-yl]oxymethyl]pyridine-2-yl]triazolo[4,5-d]pyrimidin-5-amine
Alternate Name:
Ciforadenant
Molecular Weight:
407.43
Molecular Formula:
C20H21N7O3
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
Beige solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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