CU-T12-9 | TLR 1/2 agonist

CAS:
 1821387-73-8
Catalog Number:
 10-4922

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CU-T12-9 (1821387-73-8) is a selective Toll-like receptor 1/2 (TLR1/2) agonist (EC50 = 53 nM).1 It facilitates TLR1/2 heterodimeric complex formation and not TLR2/6. CU-T12-9 activates NF-kB signaling, triggers nitric oxide production, and upregulates expression of mRNA levels for TNF and IL-10.

References/Citations:

  1. Cheng et al. (2015), Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists; Sci.  Adv. 1 e1400139
1821387-73-8, CU-T12-9, CU-T12-9 supplier, TLR1 agonist, TLR1/2 agonist, TLR2 agonist
CAS:
1821387-73-8
Catalog Number:
10-4922
Activity:
TLR1/2 agonist
Chemical Names:
N-Methyl-4-nitro-2-(-(4-(trifluoromethyl)phenyl)-1H-imidazol-1-yl)aniline
Molecular Weight:
362.31
Molecular Formula:

C17H13F3N4O2

Solubility:
Soluble in DMSO (50 mg/ml)
Physical Properties:
Yellow solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

CU-T12-9 (1821387-73-8) is a selective Toll-like receptor 1/2 (TLR1/2) agonist (EC50 = 53 nM).1 It facilitates TLR1/2 heterodimeric complex formation and not TLR2/6. CU-T12-9 activates NF-kB signaling, triggers nitric oxide production, and upregulates expression of mRNA levels for TNF and IL-10.

References/Citations:

  1. Cheng et al. (2015), Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists; Sci.  Adv. 1 e1400139

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