Cucurbitacin B | IGF2BP1 inhibitor

CAS:
 6199-67-3
Catalog Number:
 10-4881
Cucurbitacin B chemical structure

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Cucurbitacin B (6199-67-3) is a natural product isolated from the Cucurbitaceae family.1 It displays a broad range of pharmacological activities including anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepato-and neuroprotection, and anti-cancer.1,2 Cucurbitacin B’s activities are the result of regulation of diverse signaling pathways including JAK/STAT3, Nrf2/ARE, NFkB, AMPK, MAPK, and others. It has recently been shown to block the m6A RNA reader protein IGF2BP1 (IC50 = 4.1 µM and 1.0 µM @ 24 and 72 hr respectively).3 IGF2BP1 blockade in hepatocellular carcinoma cells leads to apoptosis and subsequent recruitment of immune cells to the tumor microenvironment and PD-L1 blockade.

References/Citations:

  1. Dai et al. (2023), Cucurbitacin B: A review of its pharmacology, toxicity, and pharmacokinetics; Pharmacol. Res. 187 106587
  2. Mi et al. (2025), Cucurbitacin B in cancer: A comprehensive review of its targets and molecular mechanisms; Biochem. Pharmacol. 242 (Pt.1) 117240
  3. Liu et al. (2022), Allosteric Regulation of IGF2BP1 as a Novel Strategy for the Activation of Tumor Immune Microenvironment; ACS Cent. Sci. 8 1102
6199-67-3, Cucurbitacin, Cucurbitacin B supplier, IGF2BP1 inhibitor
CAS:
6199-67-3
Catalog Number:
10-4881
Activity:
IGF2BP1 inhibitor
Chemical Names:
[(E,6R)-6-[(2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate
Alternate Name:
Amarine
Molecular Weight:
558.71
Molecular Formula:

C32H46O8

Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:

>98% TLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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Cucurbitacin B (6199-67-3) is a natural product isolated from the Cucurbitaceae family.1 It displays a broad range of pharmacological activities including anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepato-and neuroprotection, and anti-cancer.1,2 Cucurbitacin B’s activities are the result of regulation of diverse signaling pathways including JAK/STAT3, Nrf2/ARE, NFkB, AMPK, MAPK, and others. It has recently been shown to block the m6A RNA reader protein IGF2BP1 (IC50 = 4.1 µM and 1.0 µM @ 24 and 72 hr respectively).3 IGF2BP1 blockade in hepatocellular carcinoma cells leads to apoptosis and subsequent recruitment of immune cells to the tumor microenvironment and PD-L1 blockade.

References/Citations:

  1. Dai et al. (2023), Cucurbitacin B: A review of its pharmacology, toxicity, and pharmacokinetics; Pharmacol. Res. 187 106587
  2. Mi et al. (2025), Cucurbitacin B in cancer: A comprehensive review of its targets and molecular mechanisms; Biochem. Pharmacol. 242 (Pt.1) 117240
  3. Liu et al. (2022), Allosteric Regulation of IGF2BP1 as a Novel Strategy for the Activation of Tumor Immune Microenvironment; ACS Cent. Sci. 8 1102

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