Cycloastragenol | Telomerase activator/Senolytic agent

Cycloastragenol chemical structure Focus Biomolecules

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Cycloastragenol (84605-18-5) is a novel naturally occurring terpenoid found in Astragalus which was shown to be a telomerase activator.  In CD8+ T lymphocytes from HIV-infected donors it retarded telomere shortening, increased proliferative potential and enhanced cytokine/chemokine production and antiviral activity.1 It suppressed lung damage in a idiopathic pulmonary fibrosis mouse model.2 It has also been shown to be a novel senolytic agent, inducing senescent cell apoptosis and restoring physical function in mice with irradiation-induced aging.3

References/Citations:

  1. Fauce et al. (2008), Telomerase-Based Pharmacologic Enhancement of Antiviral Function of Human CD8+ T Lymphocytes; J. Immunol. 181 7400
  2. Le Saux et al. (2013), A novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis; PLoS One 8 e58423
  3. Zhang et al. (2023), Cycloastragenol: A Novel Senolytic Agent That Induces Senescent Cell Apoptosis and Restores Physical Function in TBI-Aged Mice; Int. J. Mol. Sci. 24 6554

 

84605-18-5, cycloastragenol, Cycloastragenol supplier, telomerase activator senolytic agent

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Cycloastragenol (84605-18-5) is a novel naturally occurring terpenoid found in Astragalus which was shown to be a telomerase activator.  In CD8+ T lymphocytes from HIV-infected donors it retarded telomere shortening, increased proliferative potential and enhanced cytokine/chemokine production and antiviral activity.1 It suppressed lung damage in a idiopathic pulmonary fibrosis mouse model.2 It has also been shown to be a novel senolytic agent, inducing senescent cell apoptosis and restoring physical function in mice with irradiation-induced aging.3

References/Citations:

  1. Fauce et al. (2008), Telomerase-Based Pharmacologic Enhancement of Antiviral Function of Human CD8+ T Lymphocytes; J. Immunol. 181 7400
  2. Le Saux et al. (2013), A novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis; PLoS One 8 e58423
  3. Zhang et al. (2023), Cycloastragenol: A Novel Senolytic Agent That Induces Senescent Cell Apoptosis and Restores Physical Function in TBI-Aged Mice; Int. J. Mol. Sci. 24 6554