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Product Details

Cycloheximide-N-ethylethanoate | FKBP12 inhibitor

FKBP12 inhibitor (IC50=4.4 µM) with neuroregenerative properties. Does not inhibit protein synthesis (as does cycloheximide).1 Mimics a helical peptide in target proteins for binding to the immunophillin Mip homolog, BpML1 (Burkholderia pseudomallei Mip-like protein 1).2

References/Citations

1) Christner et al. (1999), Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties; J. Med. Chem., 42 3615
2) Norville et al. (2011), The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development; Biochem. J., 437 413

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Cycloheximide-N-ethylethanoate | FKBP12 inhibitor

Catalog#  10-1062

$65.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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Catalog Number:
10-1062
Activity:
FKBP12 inhibitor
Chemical Name:
Ethyl 2-(4-((R)-2-((1S, 3S, 5S)-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)-2,6-dioxopiperidin-1-yl)acetate
Molecular Weight:
367.44
Molecular Formula:
C19H29NO6
Solubility:
Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 3 mg/ml)
Physical Properties:
White solid
Purity:
99% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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