Cycloheximide-N-ethylethanoate | FKBP12 inhibitor

FKBP12 inhibitor (IC₅₀=4.4 µM) with neuroregenerative properties. Does not inhibit protein synthesis (as does cycloheximide).¹ Mimics a helical peptide in target proteins for binding to the immunophillin Mip homolog, BpML1 (Burkholderia pseudomallei Mip-like protein 1).²

References/Citations

1) Christner et al. (1999), Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties; J. Med. Chem., 42 3615
2) Norville et al. (2011), The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development; Biochem. J., 437 413