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CYM-5541 | Allosteric sphingosine-1-phosphate receptor 3 agonist

CAS:
945128-26-7
Catalog Number:
10-4493
Activity:
Allosteric sphingosine-1-phosphate receptor 3 agonist
Chemical Name:
N,N-Dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide
Alternate Name:
ML249
Molecular Weight:
316.44
Molecular Formula:
C19H28N2O2
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 15 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

CYM-5541 (945128-26-7) is a potent and selective allosteric agonist of the sphingosine-1-phosphate receptor 3 (S1P3; EC50’s = 72.3-132 nM).1,2

References/Citations:

1) Guerrero et al. (2011), Probe Development Efforts for an Allosteric Agonist of Sphingosine 1-phosphate Receptor 3 (S1P3); Probe Reports from the NIH Molecular Libraries Program
2) Jo et al. (2012), Novel Selective Allosteric and Bitopic Ligands for the S1P3 Receptor; ACS Chem. Biol. 7 1975

CYM-5541 | Allosteric sphingosine-1-phosphate receptor 3 agonist is also available in the Cellular Metabolism Library.
CAS:
945128-26-7
Catalog Number:
10-4493
Activity:
Allosteric sphingosine-1-phosphate receptor 3 agonist
Chemical Name:
N,N-Dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide
Alternate Name:
ML249
Molecular Weight:
316.44
Molecular Formula:
C19H28N2O2
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 15 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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