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Cytochalasin D | Disrupts actin filaments

Cytochalasin D (22144-77-0) is a potent inhibitor of actin polymerization which also causes the disruption of actin filaments. More potent that cytochalasin B (10-fold) and does not inhibit monosaccharide transport across cell membranes. Disruption of actin microfilaments leads to activation of p53. Cell permeable

References/Citations
1)) Goddetteand et al. (1986), Actin polymerization. The mechanism of action of cytochalasin D; J. Biol. Chem., 261 15974
2) Rubtsova et al. (1998), Disruption of actin microfilaments by cytochalasin D leads to activation of p53; FEBS Lett., 430 353

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Catalog#  10-2071

$63.00
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CAS:
22144-77-0
Catalog Number:
10-2071
Activity:
Disrupts actin filaments
Chemical Name:
(7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione
Molecular Weight:
507.63
Molecular Formula:
C30H37NO6
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
Storage Temperature:
-20°C (des.)
Stability:
Stable for 3 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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