D159687 | Selective PDE4D inhibitor

D159687 chemical structure

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D159687 (1155877-97-6) is a potent (IC50 = 28 nM human PDE4D) and selective allosteric inhibitor of phosphodiesterase 4D (PDE4D) that increases cAMP levels and displays efficacy in cognition tests in mice and monkeys.1,2 It reversed cognitive deficits in a mouse model of traumatic brain injury.3 D159687 induced weight and fat mass loss in aged mice without changing lean mass.4 It also mitigated liver fibrosis by suppressing the expression of inflammatory and profibrogenic genes.5

References/Citations:

  1. Burgin et al. (2010), Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety; Nat. Biotechnol. 28 63
  2. Sutcliffe et al. (2014), Efficacy of selective PDE4D negative allosteric modulations in the object retrieval task in female cynomolgus monkeys (Macaca fascicularis); PLoS One 9 e102449
  3. Titus et al. (2018), A negative allosteric modulator of PDE4D enhances learning after traumatic brain injury; Neurobiol. Learn Mem. 148 38
  4. Muo et al. (2018), Compound D159687, a phosphodiesterase 4D inhibitor, induces weight and fat mass loss in aged mice without changing lean mass, physical and cognitive function; Biochem. Biophys. Res. Commun. 506 1059
  5. Kim et al. (2025), Selective inhibition of long isoforms of phosphodiesterase 4D mitigates liver fibrosis in mouse models; J. Clin. Invest. 136 182571
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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

D159687 (1155877-97-6) is a potent (IC50 = 28 nM human PDE4D) and selective allosteric inhibitor of phosphodiesterase 4D (PDE4D) that increases cAMP levels and displays efficacy in cognition tests in mice and monkeys.1,2 It reversed cognitive deficits in a mouse model of traumatic brain injury.3 D159687 induced weight and fat mass loss in aged mice without changing lean mass.4 It also mitigated liver fibrosis by suppressing the expression of inflammatory and profibrogenic genes.5

References/Citations:

  1. Burgin et al. (2010), Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety; Nat. Biotechnol. 28 63
  2. Sutcliffe et al. (2014), Efficacy of selective PDE4D negative allosteric modulations in the object retrieval task in female cynomolgus monkeys (Macaca fascicularis); PLoS One 9 e102449
  3. Titus et al. (2018), A negative allosteric modulator of PDE4D enhances learning after traumatic brain injury; Neurobiol. Learn Mem. 148 38
  4. Muo et al. (2018), Compound D159687, a phosphodiesterase 4D inhibitor, induces weight and fat mass loss in aged mice without changing lean mass, physical and cognitive function; Biochem. Biophys. Res. Commun. 506 1059
  5. Kim et al. (2025), Selective inhibition of long isoforms of phosphodiesterase 4D mitigates liver fibrosis in mouse models; J. Clin. Invest. 136 182571