Daidzein | Phytoestrogen

CAS:
 486-66-8
Catalog Number:
 10-2688

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Daidzein (486-66-8) is a phytoestrogen found in soy products.1 Inhibits insulin or IGF-1 mediated signaling in cell cycle progression in Swiss 3T3 cells.2 Improves glucose homeostasis in a type 2 diabetic mouse model.3 May be metabolized to S-equol (another phytoestrogen with greater potency) in the gut by intestinal microflora.4,5 Cell permeable and active in vivo.

References/Citations:

  1. Casanova et al. (1999), Developmental effects of dietary phytoestrogens in Sprague-Dawley rats and interactions of genistein and daidzein with rat estrogen receptors alpha and beta in vitro; Toxicol. Sci. 51 236
  2. Higashi and Ohawara. (1994), Daidzein inhibits insulin- or insulin-like growth factor-1-mediated signaling in cell cycle progression of Swiss 3T3 cells; Biochim. Biophys. Acta 1221 29
  3. Cheong et al. (2014), Daidzein promotes glucose uptake through glucose transporter 4 translocation to plasma membrane in L6 myocytes and improves glucose homeostasis in Type 2 diabetic model mice; J. Nutr. Biochem. 25 136
  4. Setchell et al. (2013), Dietary factors influence production of the soy isoflavone metabolite s-(-)equol in healthy adults; J. Nutr. 143 1950
  5. Kim et al. (2026), Microbial Production and Industrial Applications of (S)-Equol for Precision Health and Functional Food Innovation; J. Agric. Food Chem. 74 1938
486-66-8, Daidzein, Daidzein supplier
CAS:
486-66-8
Catalog Number:
10-2688
Activity:
Phytoestrogen
Chemical Names:
7-Hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Alternate Name:
4',7-Dihydroxyisoflavone
Molecular Weight:
254.24
Molecular Formula:

C15H10O4

Solubility:
Soluble in DMSO (25 mg/ml)
Physical Properties:
White solid
Purity:

>98% TLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 1 week.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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Daidzein (486-66-8) is a phytoestrogen found in soy products.1 Inhibits insulin or IGF-1 mediated signaling in cell cycle progression in Swiss 3T3 cells.2 Improves glucose homeostasis in a type 2 diabetic mouse model.3 May be metabolized to S-equol (another phytoestrogen with greater potency) in the gut by intestinal microflora.4,5 Cell permeable and active in vivo.

References/Citations:

  1. Casanova et al. (1999), Developmental effects of dietary phytoestrogens in Sprague-Dawley rats and interactions of genistein and daidzein with rat estrogen receptors alpha and beta in vitro; Toxicol. Sci. 51 236
  2. Higashi and Ohawara. (1994), Daidzein inhibits insulin- or insulin-like growth factor-1-mediated signaling in cell cycle progression of Swiss 3T3 cells; Biochim. Biophys. Acta 1221 29
  3. Cheong et al. (2014), Daidzein promotes glucose uptake through glucose transporter 4 translocation to plasma membrane in L6 myocytes and improves glucose homeostasis in Type 2 diabetic model mice; J. Nutr. Biochem. 25 136
  4. Setchell et al. (2013), Dietary factors influence production of the soy isoflavone metabolite s-(-)equol in healthy adults; J. Nutr. 143 1950
  5. Kim et al. (2026), Microbial Production and Industrial Applications of (S)-Equol for Precision Health and Functional Food Innovation; J. Agric. Food Chem. 74 1938

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