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Product Details

Damnacanthal | p56 Lck inhibitor

Damnancantal (477-84-9) is a potent inhibitor of p56lck tyrosine kinase activity (IC50 = 17 nM for inhibition of autophosphorylation). Displays 7- to 20-fold selectivity over p59fyn and p60src tyrosine kinases and > 40-fold to 100-fold selectivity over other kinases.1 Mobilizes intracellular Ca2+ in dermal fibroblasts.2 Inhibits LIM-kinase, impairing cell migration and invasion.3 A potent inhibitor of angiogenesis.4 Inhibits mast cell activation.5

References/Citations

1) Faltynek et al. (1995), Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity; Biochemistry, 34 12404
2) Aoki et al. (2000), Mechanism of damnacanthal-induced ;Ca(2+)](i) elevation in human dermal fibroblasts; Eur. J. Pharmacol., 387 119
3) Ohashi et al. (2014), Damnacanthal, an effective inhibitor of LIM-kinase, inhibits cell migration and invasion; Mol. Biol. Cell, 25 828
4) Garcia-Vilas et al. (2017), The noni anthraquinone damnacanthal is a multi-kinase inhibitor with potent anti-angiogenic effects; Cancer Letters, 385 1
5) Garcia-Vilas et al. (2015), Damnacanthal inhibits IgE receptor-mediated activation of mast cells; Mol. Immunol., 65 86

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Catalog#  10-2516-0001

$130.00
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CAS:
477-84-9
Catalog Number:
10-2516
Activity:
p56 Lck inhibitor
Chemical Name:
9,10-Dihydroxy-3-hydroxy-1-methoxy-9,10-dioxo-2-anthracenecarboxaldehyde
Molecular Weight:
282.25
Molecular Formula:
C16H10O5
Solubility:
Soluble in DMSO (up to 7 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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