Dansylcadaverine | Autophagic vacuole dye
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 100 mg | $30.00 | ||
| 250 mg | $58.00 |
Dansylcadaverine (10121-91-2) preferentially accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids making it a very useful probe for monitoring autophagy.1,2 Inhibits EGF internalization.3 Dansylcadaverine competes with certain trans-aminases and can be used with antibody/affinity procedures to isolate resulting conjugates.4 Abs: 335 nm, Em: 510 nm
References/Citations:
1) Munafo and Colombo (2001), A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation; Int. J. Cell Sci., 114 3619
2) Jiang et al. (2012), Targeting androgen receptor leads to suppression of prostate cancer via induction of autophagy; J. Urol., 188 1361
3) Haigler et al. (1980), Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells; J. Biol. Chem., 255 1239
4) Murthy et al. (1994), Residue Gln-30 of human erythrocyte anion transporter is a prime site for reaction with intrinsic transglutaminase; J. Biol. Chem., 269 22907
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Dansylcadaverine (10121-91-2) preferentially accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids making it a very useful probe for monitoring autophagy.1,2 Inhibits EGF internalization.3 Dansylcadaverine competes with certain trans-aminases and can be used with antibody/affinity procedures to isolate resulting conjugates.4 Abs: 335 nm, Em: 510 nm
References/Citations:
1) Munafo and Colombo (2001), A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation; Int. J. Cell Sci., 114 3619
2) Jiang et al. (2012), Targeting androgen receptor leads to suppression of prostate cancer via induction of autophagy; J. Urol., 188 1361
3) Haigler et al. (1980), Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells; J. Biol. Chem., 255 1239
4) Murthy et al. (1994), Residue Gln-30 of human erythrocyte anion transporter is a prime site for reaction with intrinsic transglutaminase; J. Biol. Chem., 269 22907
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