Dansylcadaverine | Autophagic vacuole dye

CAS:
10121-91-2
Catalog Number:
10-2847
Activity:
Autophagic vacuole dye
Chemical Name:
N-(5-Amino­pentyl)-5-dimethylaminonaphthalene-1-sulfonamide
Alternate Names:
Monodansyl cadaverine; MDC
Molecular Weight:
335.46
Molecular Formula:
C17H25N3O2S
Solubility:
Soluble in DMSO (up to 10 mg/ml with warming) or in Methanol (up to 10 mg/ml)
Physical Properties:
Off-white solid
Purity:
97% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or methanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
100 mg$30.00
250 mg$58.00

Dansylcadaverine (10121-91-2) preferentially accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids making it a very useful probe for monitoring autophagy.1,2 Inhibits EGF internalization.3 Dansylcadaverine competes with certain trans-aminases and can be used with antibody/affinity procedures to isolate resulting conjugates.4 Abs: 335 nm, Em: 510 nm

References/Citations:

1) Munafo and Colombo (2001), A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation; Int. J. Cell Sci., 114 3619
2) Jiang et al. (2012), Targeting androgen receptor leads to suppression of prostate cancer via induction of autophagy; J. Urol., 188 1361
3) Haigler et al. (1980), Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells; J. Biol. Chem., 255 1239
4) Murthy et al. (1994), Residue Gln-30 of human erythrocyte anion transporter is a prime site for reaction with intrinsic transglutaminase; J. Biol. Chem., 269 22907

CAS:
10121-91-2
Catalog Number:
10-2847
Activity:
Autophagic vacuole dye
Chemical Name:
N-(5-Amino­pentyl)-5-dimethylaminonaphthalene-1-sulfonamide
Alternate Names:
Monodansyl cadaverine; MDC
Molecular Weight:
335.46
Molecular Formula:
C17H25N3O2S
Solubility:
Soluble in DMSO (up to 10 mg/ml with warming) or in Methanol (up to 10 mg/ml)
Physical Properties:
Off-white solid
Purity:
97% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or methanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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