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Product Details

Dantrolene Na | SR calcium release inhibitor

Dantrolene Na (14663-23-1) inhibits release of Ca2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor channels with selectivity for RYR1 and RYR3 over RYR2.1 Protects against quisqualate and NMDA-induced cytotoxicity in cultured cerebral cortical neurons.2  Displays neuroprotective effects.3 Prevents cell death in neural progenitor cells derived from Wolfram syndrome iPS cells.4


1) Zhao et al. (2001), Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity; J. Biol. Chem., 276 13810
2) Frandsen and Schousboe (1992), Mobilization of dantrolene-sensitive intracellular calcium pools is involved in the cytotoxicity induced by quisqualate and N-methyl-D-aspasrtate but not by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionate and kainite in cultured cerebral cortical neurons; Proc. Natl. Acad. Sci. USA, 89 2590
3) Muehlschlegel and Sims (2009), Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unit; Neuro. Crit. Care, 10 103
4) Lu et al. (2014), A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome; Proc. Natl. Acad. Sci. USA, 111 E5292

Focus Biomolecules cell signaling supplier, chemical structure Dantrolene Na | SR calcium release inhibitor | CAS 14663-23-1

Catalog#  10-2208-0100

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Catalog Number:
SR calcium release inhibitor
Chemical Name:
1-[(5-(p-Nitrophenyl)furfurylidene)amino]hydantoin sodium salt
Molecular Weight:
Molecular Formula:
C14H9N4O5 Na
Soluble in DMSO (up to 3 mg/ml) or in a 1:1 mix of DMF and Ethanol (up to 20 mg/ml)
Physical Properties:
Orange solid
99% by HPLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stable for 1 year as supplied. Solutions in DMSO or DMF/ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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