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Product Details

Dantrolene Na | SR calcium release inhibitor

Dantrolene Na (14663-23-1) inhibits release of Ca2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor channels with selectivity for RYR1 and RYR3 over RYR2.1 Protects against quisqualate and NMDA-induced cytotoxicity in cultured cerebral cortical neurons.2  Displays neuroprotective effects.3 Prevents cell death in neural progenitor cells derived from Wolfram syndrome iPS cells.4

References/Citations

1) Zhao et al. (2001), Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity; J. Biol. Chem., 276 13810
2) Frandsen and Schousboe (1992), Mobilization of dantrolene-sensitive intracellular calcium pools is involved in the cytotoxicity induced by quisqualate and N-methyl-D-aspasrtate but not by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionate and kainite in cultured cerebral cortical neurons; Proc. Natl. Acad. Sci. USA, 89 2590
3) Muehlschlegel and Sims (2009), Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unit; Neuro. Crit. Care, 10 103
4) Lu et al. (2014), A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome; Proc. Natl. Acad. Sci. USA, 111 E5292

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Catalog#  10-2208-0100

$50.00
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CAS:
14663-23-1
Catalog Number:
10-2208
Activity:
SR calcium release inhibitor
Chemical Name:
1-[(5-(p-Nitrophenyl)furfurylidene)amino]hydantoin sodium salt
Molecular Weight:
336.23
Molecular Formula:
C14H9N4O5 Na
Solubility:
Soluble in DMSO (up to 3 mg/ml) or in a 1:1 mix of DMF and Ethanol (up to 20 mg/ml)
Physical Properties:
Orange solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or DMF/ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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