Antitumor antibiotic used in the treatment of acute myeloid leukemias.1 Induces DNA damage by intercalation.2 Induces apoptosis in a variety of cell lines.3 Inhibition of autophagy with chloroquine enhances daunorubicin-induced apoptosis in K562 cells.4 Cell permeable.
1) Laurent and Jaffrezou (2001), Signaling pathways activated by daunorubicin; Blood 98 913
2) Noel et al. (2008), Parallel improvement of sodium and chloride transport defects by miglustat (n-butyldeoxynojyrimicin) in cystic fibrosis; J. Pharmacol. Exp. Ther., 325 1016
3) Masquelier et al. (2004), Relationship between daunorubicin concentration and apoptosis induction in leukemic cells; Biochem.Pharmacol. 67 1047
4) Han et al. (2011), Autophagy inhibition enhances daunorubicin-induced apoptosis in K562 cells; PLoS One 6 e28491