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Product Details

Daunorubicin HCl | DNA Damaging Agent / Anticancer Agent

Antitumor antibiotic used in the treatment of acute myeloid leukemias.1 Induces DNA damage by intercalation.2 Induces apoptosis in a variety of cell lines.3 Inhibition of autophagy with chloroquine enhances daunorubicin-induced apoptosis in K562 cells.4 Cell permeable.

References/Citations

1) Laurent and Jaffrezou (2001), Signaling pathways activated by daunorubicin; Blood 98 913
2) Noel et al. (2008), Parallel improvement of sodium and chloride transport defects by miglustat (n-butyldeoxynojyrimicin) in cystic fibrosis; J. Pharmacol. Exp. Ther., 325 1016
3) Masquelier et al. (2004), Relationship between daunorubicin concentration and apoptosis induction in leukemic cells; Biochem.Pharmacol. 67 1047
4) Han et al. (2011), Autophagy inhibition enhances daunorubicin-induced apoptosis in K562 cells; PLoS One 6 e28491

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Catalog#  10-2429-0010

$60.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
23541-50-6
Catalog Number:
10-2429
Activity:
DNA Damaging Agent / Anticancer agent
Alternate Names:
Daunomycin; rubidomycin; RP-13057
Molecular Weight:
536.98
Molecular Formula:
C27H39NO10 • HCl
Solubility:
Soluble in water (up to 25 mg/ml)
Physical Properties:
Red solid
Purity:
95% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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