DBIC | DNMT3B S-nitrosylation inhibitor
Available Options
| Size | Price | Quantity | |
|---|---|---|---|
| 5mg | $75.00 | ||
| 25mg | $300.00 |
DBIC (487026-67-5) specifically inhibits S-nitrosylation of DNA methyltransferase 3B (DNMT3B) at low concentrations, IC50≤100 nM, without affecting its enzymatic activity. Treatment with DBIC prevents nitric oxide-induced conversion of human colonic adenoma to adenocarcinoma in vitro. Treatment with DBIC strongly attenuates tumor development in a mouse model of carcinogenesis triggered by inflammation-induced NO production. DNMT3B-mediated DNA methylation is regulated by S-nitrosylaton and DBIC represents a new useful tool for studying this system.1 A negative control compound, DBIC-neg2 (Cat # 10-5162) is also available.
- Okuda et al. (2023), Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis; Nat. Commun, 14 621
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Product Data Sheet:
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DBIC (487026-67-5) specifically inhibits S-nitrosylation of DNA methyltransferase 3B (DNMT3B) at low concentrations, IC50≤100 nM, without affecting its enzymatic activity. Treatment with DBIC prevents nitric oxide-induced conversion of human colonic adenoma to adenocarcinoma in vitro. Treatment with DBIC strongly attenuates tumor development in a mouse model of carcinogenesis triggered by inflammation-induced NO production. DNMT3B-mediated DNA methylation is regulated by S-nitrosylaton and DBIC represents a new useful tool for studying this system.1 A negative control compound, DBIC-neg2 (Cat # 10-5162) is also available.
- Okuda et al. (2023), Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis; Nat. Commun, 14 621
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