DC-Y13-27 | YTHDF2 inhibitor

CAS:
 3069691-93-6
Catalog Number:
 10-4884
DC-Y13-27 chemical structure

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DC-Y13-27 (3069691-93-6) is an inhibitor (IC50 = 21.8 µM) of the RNA N6-methyladenosine (m6A) reader YTHDF2.1 It significantly enhanced tumor growth inhibition in MC38 murine models in conjunction with radiotherapy and/or anti-PD-L1 therapy via an increase in the number of CD8+ T cells.

References/Citations:

  1. Wang et al. (2023), YTHDF2 inhibition potentiates radiotherapy anti-tumor efficacy; Cancer Cell 41 1294
3069691-93-6, DC-Y13-27, DC-Y13-27 supplier, DCY1327, YTHDF2 inhibitor
CAS:
3069691-93-6
Catalog Number:
10-4884
Activity:
YTHDF2 inhibitor
Chemical Names:
(E)-2-Cyano-3-[5-(3-hydroxyphenyl)thiophen-2-yl]prop-2-enamide
Alternate Name:
(E)-2-Cyano-3-[5-(3-hydroxyphenyl)thiophen-2-yl]acrylamide
Molecular Weight:
270.31
Molecular Formula:

C14H10N2O2S

Solubility:
Soluble in DMSO (>50 mg/ml)
Physical Properties:
Yellow solid
Purity:

>98% TLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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DC-Y13-27 (3069691-93-6) is an inhibitor (IC50 = 21.8 µM) of the RNA N6-methyladenosine (m6A) reader YTHDF2.1 It significantly enhanced tumor growth inhibition in MC38 murine models in conjunction with radiotherapy and/or anti-PD-L1 therapy via an increase in the number of CD8+ T cells.

References/Citations:

  1. Wang et al. (2023), YTHDF2 inhibition potentiates radiotherapy anti-tumor efficacy; Cancer Cell 41 1294

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