DC2-C1 | YTHDC2 inhibitor

CAS:
 N/A
Catalog Number:
 10-4889
DC2-C1 chemical structure

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DC2-C1 is a potent (IC50 = 168 nM) inhibitor of the RNA N6-methyladenosine reader YTHDC2.  YTHDC2 can act as both a tumor suppressor and oncogene as well as being involved in metabolic regulation. DC2-C1 is selective for YTHDC2 over other YTH-domain proteins. Cell permeable.

References/Citations:

  1. Yang et al. (2026), Deep learning-assisted discovery of a potent and cell-active inhibitor of RNA N6-methyladenosine recognition protein YTHDC2; Nat. Commun. 17 46
DC2-C1, DC2-C1 supplier, YTHDC2 inhibitor
CAS:
N/A
Catalog Number:
10-4889
Activity:
YTHDC2 inhibitor
Chemical Names:
N-(5-Bromo-3-chloro-2-hydroxyphenyl)-2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetamide
Molecular Weight:
472.72
Molecular Formula:

C22H15BrClNO4

Solubility:
Soluble in DMSO (>80 mg/ml)
Physical Properties:
Pale pink solid
Purity:

>98% TLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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DC2-C1 is a potent (IC50 = 168 nM) inhibitor of the RNA N6-methyladenosine reader YTHDC2.  YTHDC2 can act as both a tumor suppressor and oncogene as well as being involved in metabolic regulation. DC2-C1 is selective for YTHDC2 over other YTH-domain proteins. Cell permeable.

References/Citations:

  1. Yang et al. (2026), Deep learning-assisted discovery of a potent and cell-active inhibitor of RNA N6-methyladenosine recognition protein YTHDC2; Nat. Commun. 17 46

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