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DC260126 | GPR40 antagonist

DC260126 (346692-04-4) is a GPR40 receptor antagonist1. Suppresses fatty acid-induced elevation of intracellular Ca++. Inhibits palmitic acid potentiated glucoseÐstimulated insulin secretion in Min6 pancreatic β cells in vitro. DC260126 lowers serum insulin levels, increases insulin sensitivity2 in obese Zucker rats (6 mg/kg)2. Reduces pancreatic β cell apoptosis in obese diabetic (db/db) rats3. Protects Min6 β cells from palmitic acid-induced ER stress and apoptosis4

References/Citations
1) Hu et al. (2009), A novel class of antagonist for the FFAs receptor GPR40; Biochem. Biophys. Res. Commun., 390 557
2) Zhang et al. (2010), DC260126, a small molecule antagonist of GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats; Biomed. Pharmacother., 64 647
3) Sun et al. (2013), DC260126: a small molecule antagonist of GPR40 that protects against pancreatic β-cells dysfunction in db/db mice; PLoS One., 8(6) e66744
4) Wu et al. (2012), Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis; J. Biochem, 113 1152

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Focus Biomolecules cell signaling reagent supplier, chemical structure of DC260126 | GPR40 antagonist | CAS 346692-24-4

Catalog#  10-1531

$48.00
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CAS:
346692-04-4
Catalog Number:
10-1531
Activity:
GPR40 antagonist
Chemical Name:
N-(4-Butylphenyl)-4-fluorobenzenesulfonamide
Molecular Weight:
307.37
Molecular Formula:
C16H18NO2S
Solubility:
Soluble in DMSO (up to 80 mg/ml) or in Ethanol (up to 80 mg/ml).
Physical Properties:
Brown waxy solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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