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Product Details

Decylubiquinone | MPTP inhibitor

Decylubiquinone (55486-00-5) inhibits the Ca2+ dependent mitochondrial permeability transition pore (MPTP) without inhibiting respiration.1 Maximum effect on Ca2+ retention capacity of rat liver mitochondria at 100 μM. Inhibits etoposide-induced apoptosis in in L929 cells at 5 μM via inhibition of cytochrome C release.2 Delays rotenone-induced cardiac dysfunction in a zebrafish model of development and cardiovascular function.3 Substrate for various quinone oxidoreductases.4,5

References/Citations

1) Fontaine et al. (1998), A Ubiquinone-binding Site Regulates the Mitochondrial Permeability Transition Pore; J. Biol. Chem., 273 25734
2) Karpinich et al. (2002), The course of Etoposide-Induced Apoptosis from Damage to DNA and p53 Activation to Mitochodrial Release of Cytochrome c; J. Biol. Chem., 277 16547
3) Pinho et al. (2013) How mitochondrial dysfunction affects zebrafish development and cardiovascular function: an in vivo model for testing mitochondria-targeted drugs; Br. J. Pharmacol., 169 1072
4) Kunow et al. (1994) F420H2: quinone oxidoreductase from Archaeoglobus fulgidus. Characterization of a membrane-bound multisubunit complex containing FAD and iron-sulfur clusters; Eur. J. Biochem., 223 503
5) Zickermann et al (1998) Analysis of the pathogenic human mitochondria mutation ND1/3460 and mutations of strictly conserved residues in it’s vicinity, using the bacterium Paracoccis denitrificans; Biochemistry, 37 11792

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Decylubiquinone | MPTP inhibitor | CAS 55486-00-5

Catalog#  10-2580-0010

$48.00
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CAS:
55486-00-5
Catalog Number:
10-2580
Activity:
MPTP inhibitor
Chemical Name:
2,3-Dimethoxy-5-methyl-6-decyl-1,4-benzoquinone
Molecular Weight:
322.44
Molecular Formula:
C19H30O4
Solubility:
Soluble in DMSO (up to 10 mg/ml)
Physical Properties:
Yellow or orange oil
Purity:
97% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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