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Deltamethrin | Calcineurin inhibitor; displays neurotrophic activity

Deltamethrin (52918-63-5) is reported to be an inhibitor of calcineurin (PP2B), IC50~100 pM1 but this activity has been disputed2. Markedly enhances the expression of BDNF in cultured rat cortical neurons and displays neurotrophic effects.3 Produces antidepressant-like effects in mice.4 Blocks the spontaneous down-regulation of Nav1.8 sodium channels expressed in Xenopus oocytes.5

References/Citations

1) Enan et al. (1992), Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides; Biochem. Pharmacol., 43 1777
2) Swingle et al. (2007), Small-molecules inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse; Methods Mol. Biol., 365 23
3) Ihara et al. (2012), Deltamethrin, a type II pyrethroid insecticide, has neurotrophic effects on neurons with continuous activation of the Bdnf promoter; Neuropharmacology, 62 1091
4) Takasaki et al. (2013), Type II pyrethroid deltamethrin produces antidepressant-like effects in mice; Behav. Brain Res., 257 182
5) Choi & Soderlund (2004), Cyclopsorin A and deltamethrin block the downregulation of Nav1.8 sodium channels expressed in Xenopus oocytes; Neurosci. Lett., 367 389
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Catalog#  10-3103-0005

$55.00
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CAS:
52918-63-5
Catalog Number:
10-3103
Activity:
Calcineurin inhibitor; displays neurotrophic activity
Chemical Name:
(S)-α-Cyano-3-phenoxybenzyl (1R, 3R)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate
Molecular Weight:
505.20
Molecular Formula:
C22H19Br2NO3
Solubility:
Soluble in DMSO (up to 50 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC and GC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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