DEPMPO (157230-67-6) is a spin trap capable of detecting oxygen, nitrogen, sulfur and carbon-centered free radicials both in vitro and in vivo. DEPMPO is useful for distinguishing between superoxide-dependent pathways of hydroxyl radical generation, and those that are superoxide independent.
1) Liu et al. (1999), Evaluation of DEPMPO as a spin trapping agent in biological systems; Free Radic. Biol. Med., 26 714
2) Shi et al. (2005), Evaluation of spin trapping agents and trapping conditions for detection of cell-generated reactive oxygen species; Arch. Biochem. Biophys., 437 59
3) Culcasi et al. (2012), EPR spin trapping evaluation of ROS production in human fibroblasts exposed to cerium oxide nanoparticles: evidence for NADPH oxidase and mitochondrial stimulation; Chem. Biol. Interact., 199 161