DHP-103 | Selective KCa3.1 blocker
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $75.00 | ||
| 25 mg | $260.00 |
DHP-103 (2775311-82-3) is a potent (IC50 = 6 nM) blocker of the intermediate-conductance calcium-activated potassium channel KCa3.1. It displays exquisite selectivity over calcium channels. It blocked mutant KCa3.1 channels that cause hereditary xerocytosis and reduced infarct volume, improved balance beam performance, and reduced activated microglia in a rat model of acute ischemic stroke.
- Ong et al. (2025), Design of structural basis of selective 1,4-dihydropyridine inhibitors of the calcium-activated potassium channel KCa3.1 ; Proc. Natl. Acad. Sci. USA 122 e2425494122
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
DHP-103 (2775311-82-3) is a potent (IC50 = 6 nM) blocker of the intermediate-conductance calcium-activated potassium channel KCa3.1. It displays exquisite selectivity over calcium channels. It blocked mutant KCa3.1 channels that cause hereditary xerocytosis and reduced infarct volume, improved balance beam performance, and reduced activated microglia in a rat model of acute ischemic stroke.
- Ong et al. (2025), Design of structural basis of selective 1,4-dihydropyridine inhibitors of the calcium-activated potassium channel KCa3.1 ; Proc. Natl. Acad. Sci. USA 122 e2425494122
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