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Difluoromethylornithine HCl | Inhibits polyamine biosynthesis

Difluoromethylornithine HCl (96020-91-6) is a selective inhibitor of ornithine decarboxylase.1 Induces apoptosis in a variety of cells.2 Difluoromethylornithine HCl displays cancer chemopreventive activity.3 Cell permeable. Active in vivo.

References/Citations
1) Verma et al. (1990), Inhibition of tumor promotion by DL-alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase; Basic Life Sci., 52 195
2) Takahashi et al. (2000), Alpha-difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model; Int. J. Cancer, 85 243
3) Meyskens et al. (1999), Development of difluoromethylornithine (DFMO) as a chemoprevention agent; Clin. Cancer Res., 5 945

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Catalog#  10-2274

$30.00
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CAS:
96020-91-6
Catalog Number:
10-2274
Activity:
Inhibits polyamine biosynthesis
Alternate Names:
DFMO; Eflornithine
Chemical Name:
DL-α-Difluoromethylornithine Hydrochloride Monohydrate
Molecular Weight:
236.65
Molecular Formula:
C6H12F2N2O2 HCl H2O
Solubility:
Soluble in Water (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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