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Dihydroresveratrol | Resveratrol metabolite

Dihydroresveratrol (58436-28-5) is a metabolite of resveratrol produced by gut microbiota.1-3 Glucoronide conjugates are found in human urine after oral intake of resveratrol-containing dietary supplements.4 Dihydroresveratrol glucoside is a potent melanogenesis inhibitor in B16F0 melanoma cells.5 Inactive analog of resveratrol in induction of premature senescence.6

1) Jung et al. (2009), Interaction of dietary resveratrol with animal-associated bacteria; FEMS Microbiol. Lett., 297 266
2) Bode et al. (2013), In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota; Am. J. Clin. Nutr., 97 295
3) Jarosova et al. (2019), Metabolism of Stilbenoids by Human Faecal Microbiota; Molecules, 24 E1155
4) Radco et al. (2013), Semi-preparative isolation of dihydroresveratrol-3-O-ß-d-glucuronide and four resveratrol conjugates from human urine after oral intake of a resveratrol-containing dietary supplement; J. Chrmoatogr. B Analyt. Technol. Biomed. Life Sci., 930 54
5) Oode et al. (2014), Synthesis of dihydroresveratrol glycosides and evaluation of their activity against melanogenesis in B16F0 melanoma cells; Eur. J. Med. Chem., 87 862
6) Faragher et al. (2011), Resveratrol, but not dihydroresveratrol, induces premature senescence in primary human fibroblasts; Age (Dordr.), 33 555

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Catalog#  10-2790-0005

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Catalog Number:
Resveratrol metabolite
Chemical Name:
5-[2-(4-Hydroxyphenyl)ethyl]-1,3-benzenediol; 3,4',5-trihydroxybibenzyl
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 30 mg/ml).
Physical Properties:
Off-white solid
98% by HPLC and TLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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