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Product Details

DiMNF | AhR modulator (SAhRM)

DiMNF (14756-24-2) is a selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). It exhibits antiinflammatory activity including suppression of cytokine-mediated acute phase genes through dissociation of non-dioxin-response element (DRE) AHR activity from DRE-dependent xenobiotic gene expression.1 DiMNF represses the cytokine-mediated induction of CD55 and therefore may have therapeutic potential in regulating the immune response to tumor formation.2 Represses estrogen-inducible transcription.3

References/Citations

1) Murray et al. (2011), Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3’,4’-dimethoxy-α-naphthoflavone;  Mol. Pharmacol., 79 508
2) Narayanan et al. (2012), Selective aryl hydrocarbon receptor modulator-mediated repression of CD55 expression induced by cytokine exposure;  J. Pharmacol. Exp. Ther., 342 345
3) Labrecque et al. (2012), Distinct roles for aryl hydrocarbon receptor nuclear translocator and ah receptor in estrogen-mediated signaling in human cancer cell lines;  PLoS One, 7(1) e29545

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DiMNF | 14756-24-2 | Structure | Supplier

Catalog#  10-1557-0010

$70.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
14756-24-2
Catalog Number:
10-1557
Activity:
AhR modulator (SAhRM)
Chemical Name:
2-(3,2-Dimethoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one
Alternate Names:
3’,4’-Dimethoxy-α-naphthoflavone
Molecular Weight:
332.45
Molecular Formula:
C21H16O4
Solubility:
Soluble in DMSO (up to 1.5 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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