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Product Details

Diphenyleneiodonium chloride | Flavoprotein inhibitor

Diphenyleneiodonium chloride (4673-26-1) is an irreversible inhibitor of iNOS and eNOS (IC50s=50 and 100 nM respectively).1 Binds to and inhibits the flavoprotein of neutrophil NADPH oxidase.2 Novel agonist for GPR3.3 Inhibits NFκB activation induced by IL-1β. Prevents early alcohol-induced liver injury in rodent models.5



1) Stuehr et al. (1991), Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs; FASEB J., 5 98
2) Yea et al. (1990), Purification and some properties of the 45 kDa diphenylene iodonium-binding flavoprotein of neutrophil NADPH oxidase; Biochem. J., 265 95
3) Ye et al. (2014), Identification of a novel small-molecule agonist for human G protein-coupled receptor 3; J. Pharmacol. Exp. Ther., 349 4371
4) Mendes et al. (2001), Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced by IL-1beta: involvement of reactive oxygen species; Mediators Inflamm., 10 209
5) Kono et al. (2001), Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat; Am. J. Physiol. Gastrointest. Liver Physiol., 280 G1005

Focus Biomolecules supplier, chemical structure of Diphenyleneiodonium chloride | Flavoprotein inhibitor | CAS 4673-26-1

Catalog#  10-2668-0010

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Catalog Number:
Flavoprotein inhibitor
Alternate Names:
Molecular Weight:
Molecular Formula:
C12H8I • Cl
Soluble in DMSO (up to 5 mg/ml with warming)
Physical Properties:
White solid
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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