DJ-V 159 | GPRC6A agonist; Stimulates insulin secretion in beta cells
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $200.00 |
GPRC6A is the receptor for osteocalcin as well as structurally unrelated ligands including L-amino acids, cations and anabolic steroids.1 GPRC6A is a potential therapeutic target for treating type 2 diabetes.2 DJ-V 159 (2253744-53-3) is an agonist at GPRC6A which activates ERK and upregulates cAMP levels in HEK-193 cells expressing GPRC6A. It stimulates insulin secretion in mouse β-cells and lowers blood glucose in mouse models.3
References/Citations:
1) Pi and Quarles (2012), Multiligand specificity and wide tissue expression of GPRC6A reveals new endocrine networks; Endocrinology, 153 2062
2) Pi et al. (2016), GPRC6A: Jack of all metabolism (or master of none); Mol. Metab., 6 185
3) Pi et al. (2018), Computationally identified novel agonists for GPRC6A; PLoS One, 13 e0195980
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
GPRC6A is the receptor for osteocalcin as well as structurally unrelated ligands including L-amino acids, cations and anabolic steroids.1 GPRC6A is a potential therapeutic target for treating type 2 diabetes.2 DJ-V 159 (2253744-53-3) is an agonist at GPRC6A which activates ERK and upregulates cAMP levels in HEK-193 cells expressing GPRC6A. It stimulates insulin secretion in mouse β-cells and lowers blood glucose in mouse models.3
References/Citations:
1) Pi and Quarles (2012), Multiligand specificity and wide tissue expression of GPRC6A reveals new endocrine networks; Endocrinology, 153 2062
2) Pi et al. (2016), GPRC6A: Jack of all metabolism (or master of none); Mol. Metab., 6 185
3) Pi et al. (2018), Computationally identified novel agonists for GPRC6A; PLoS One, 13 e0195980
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
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