Dofetilide (115256-11-6) is a clinically useful class III antiarrhythmic that inhibits the rapid component of the delayed rectifier outward potassium current (IKr) via selective blockage of the Kv11.1 (hERG) channel.1,2
References/Citations
1) Gwilt et al. (1991) UK-68,798: a novel, potent and highly selective classIII antiarrhythmic agent which blocks potassium channels in cardiac cells; J. Pharmacol. Exp. Ther., 256 318
2) Snyders and Chaudhary, (1996) High affinity open channel block by dofetilide of HERG expressed in a human cell line; Mol. Pharmacol., 49 949