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Dofetilide | hERG channel blocker
Dofetilide (115256-11-6) is a clinically useful class III antiarrhythmic that inhibits the rapid component of the delayed rectifier outward potassium current (IKr) via selective blockage of the Kv11.1 (hERG) channel.1,2
References/Citations
1) Gwilt et al. (1991) UK-68,798: a novel, potent and highly selective classIII antiarrhythmic agent which blocks potassium channels in cardiac cells; J. Pharmacol. Exp. Ther., 256 318
2) Snyders and Chaudhary, (1996) High affinity open channel block by dofetilide of HERG expressed in a human cell line; Mol. Pharmacol., 49 949
Catalog# 10-1151
$65.00
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CAS:
115256-11-6
Catalog Number:
10-1151
Activity:
hERG channel blocker
Alternate Names:
Tikosyn
Chemical Name:
N-[4-(2-{[2-(4-Methanesulfonamidophenoxy)ethyl](methyl)amino}ethyl)phenyl]methanesulfonamide
Molecular Weight:
441.56
Molecular Formula:
C19H27N3O5S2
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
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