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Product Details

Dovitinib | Kinase inhibitor

Dovitinib (405169-16-6) is a potent kinase inhibitor. Inhibits FLT3 (IC50 = 1 nM), c-KIT (IC50 = 2 nM), FGFR (IC50 = 8 nM), VEGFR1/2/3 (IC50 = 10 nM), PDGFRβ (IC50 = 27 nM), and CSF-1R (IC50 = 36 nM).1 Active in cell culture and in whole animals. Dovitinib selectively blocks the growth B9 cells transformed by wild type, or activated mutant FGFR3. Induces apoptosis, or sensitizes cells to induction of apoptosis by other means in a variety of cancer cell lines.

References/Citations
1) Lee et al. (2005), In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models; Clin. Cancer Res., 11 3633
2) Xin et al. (2006), CHIR-258 is efficacious in a newly developed fibroblast growth factor receptor 3-expressing orthotopic multiple myeloma model in mice; Clin. Cancer Res., 12 4908

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Dovitinib | Kinase inhibitor | CAS 405169-16-6

Catalog#  10-2129

$75.00
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CAS:
405169-16-6
Catalog Number:
10-2129
Activity:
Kinase inhibitor
Alternate Names:
TKI-258, CHIR258
Chemical Name:
4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one
Molecular Weight:
392.43
Molecular Formula:
C21H21FN6O
Solubility:
Soluble in DMSO (up to 30 mg/ml).
Physical Properties:
Yellow-green solid
Purity:
99% by TLC
99% by HPLC
Storage Temperature:
-20°
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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