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Product Details

Doxorubicin HCl | DNA damaging agent

Doxorubicin HCl (25316-40-9) is an antitumor antibiotic. Induces DNA damage by intercalation1 and inhibition of topoisomerase II. Doxorubicin HCl induces apoptosis in a variety of cell lines2. Acts as a substrate for MDR13. Cell permeable.

References/Citations
1) Zeman et al. (1998), Characterization of covalent adriamycin-DNA adducts; Proc. Natl. Acad. Sci., 95 11561
2) Katoh et al. (1998), Vascular endothelial growth factor inhibits apoptotic death in hematopoietic cells after exposure to chemotherapeutic drugs by inducing MCL1 acting as an antiapoptotic factor; Cancer Res., 58 5565
3) Perez et al. (2011), Anti-MDR-1 siRNA restores chemosensitivity in chemoresistant breast carcinoma and osteosarcoma cell lines; Anticancer Res., 31 2813

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Catalog#  10-2130

$70.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
25316-40-9
Catalog Number:
10-2130
Activity:
DNA damaging agent
Alternate Names:
Adriamycin; NSC-123127
Molecular Weight:
579.99
Molecular Formula:
C27H29NO11 HCl
Solubility:
Soluble in Water (up to 25 mg/ml).
Physical Properties:
Red-orange solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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