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DZNep | Methyltransferase inhibitor

DZNep (102052-95-9) is a potent histone methyltransferase inhibitor which decreases global histone methylation.1 Inhibits trimethylation of H3K27 and H4K20 in vitro.1 Selectively induces apoptosis in multiple cancer cell lines with no effect on normal cells.2 DZNep may be used in cocktails to chemically induce pluripotent stem cells (CiPSCs) from somatic cells.3 Enhances angiogenesis in a mouse model of limb ischemia.4

References/Citations

1) Miranda et al. (2009), DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation; Mol. Cancer Ther., 8 1579
2) Tan et al. (2007), Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells; Genes Dev., 21 1050
3) Hou et al. (2013), Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds; Science, 341 651
4) Mitic et al. (2015), EZH2 modulates angiogenesis in vitro and in a mouse model of limb ischemia; Mol. Ther., 23 32

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Focus Biomolecules cell signaling reagent supplier, chemical structure DZNep | Methyltransferase inhibitor | CAS 102052-95-9

Catalog#  10-1524-0001

$142.00
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CAS:
102052-95-9
Catalog Number:
10-1524
Activity:
Methyl transferase inhibitor
Chemical Name:
(1S,2R,5R)-5-(4-Aminoimidazo[4,5-c]pyridine-1-yl)-3-(hydroxymethyl)-cyclopent-3-ene-1,2-diol
Alternate Names:
3-Deazaneplanocin A; NSC 617989
Molecular Weight:
262.26
Molecular Formula:
C12H14N4O3
Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
Beige solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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